Painless 1999-2006 GM Gen III 4.8, 5.3 & 6.0L Throttle by Wire Harness Standard Length

Item #32374

Made in the USA
Painless 1999-2006 GM Gen III 4.8, 5.3 & 6.0L Throttle by Wire Harness Standard Length
1999-2006 GM Gen III 4.8/5.3/6.0L EFI Harness - Throttle by Wire - 60221
- +
Quantity: close


This harness is standalone and is not intended to replace the OEM engine wiring. Standalone harnesses are intended to run the designated engine & transmission only, generally when swapped into another vehicle.

This harness is designed for use on the 1999-2006 4.8L, 5.3L, 6.0L throttle by wire engines with a 4L60E, 4L65E, 4L70E, 4L80E, 4L85E, or manual transmission. These engines were found in factory 2003-2006 Vortec Trucks. 1999-2002 engines will require installing a 2003-2006 TBW throttle body. Engine codes supported are LR4, LM7, LM4, LQ4 and LQ9. This harness will support flex fuel and non flex fuel engines. Flex fuel engines will require an inline fuel composition sensor in order to run E85 fuel. Included with this harness is a 10 circuit weatherproof fuse block & mounting bracket and GM color coded wires with labels for easy installation.

This standard length harness allows four feet from the back of the intake manifold to where the fuseblock and ECM mount. Perfect for those that plan to mount these components under the dash or in the glove box.

This kit includes:

  1. All new fuel injection harness with OEM fitment connectors and harness breakouts
  2. OBDII connector, mounting bracket and check engine light
  3. Crimp-on terminals, rubber grommet
  4. Mounting hardware

We recommend checking the online manual for the full list of required mating parts prior to ordering.


(1) 1999-2006 GM Gen III 4.8/5.3/6.0L EFI Harness - Throttle by Wire



Part Number: 60221
Year: 1999 - 2006
Make: General Motors
Model: C & K Truck/SUV
Engine: 4.8L, 5.3L, 6.0L w/ Throttle By Wire
Trans.: 4L60E, 4L65E, 4L70E, 4L80E, 4L85E, or manual

Number of Circuits: 10 Fuses with 2 Ignition, 1 Cooling Fan & 1 Fuel Pump Relay
Harness Length: 4 Feet Between Engine and ECM
Fuse Type: Mini Blade
Firewall Pass through: Grommet
Color Code Based: 1999 - 2006 C/K Truck
Circuit Designations: Printed Wire Tags on all Connectors and Open Ended Wires

The Fuse Block Protects The Following Circuits:

• Brake and Cruise Switch
• Dual 40 amp Ignition Relays
• ECM B+
• Fuel Injectors
• Fuel Pump
• Heated O2 Sensors
• Ignition Coils
• Mass Airflow and Fuel Compensation Sensor
• Throttle Actuator Control Module
• Transmission and Park Neutral Position Switch
• 20 Amp Cooling Fan Relay
• 20 Amp Fuel Pump Relay

This harness includes connections for the following components:

• A/C Request
• Accelerator Pedal Position Sensor
• Alternator
• Brake Switch
• Cam Position Sensor
• Cooling Fans
• Crank Position Sensor
• Cruise Control
• Data Link Connector
• Driver/Pass Front O2 Sensors
• Engine Coolant Temperature
• Fuel Compensation Sensor
• Fuel Pump
• Fuel Pump Test
• Grounds
• Ignition Coils
• Ignition Switch Signal
• Injectors - Gas & Flex Fuel Sub-Harness
• Input Speed Sensor
• Knock Sensors
• Malfunction Indicator Lamp
• MAP Sensor
• Mass Airflow / Intake Air Temperature Sensor
• Output Speed Sensor
• Park/Neutral Switch
• Reverse Lights
• Starter
• Starter Relay Activation
• Tachometer
• Throttle Actuator Control Module
• Throttle Actuator Control Module to Accelerator Pedal Pigtail
• Throttle Body
• Transmission
• VSS Output for Speedometer
• Knock Sensor Pigtail


1 Year Manufacturers Warranty

Eastwood Offers Free Lifetime Technical Support

Click here for product SDS information

Attention California Residents - Proposition 65

Proposition 65 Warning WARNING - Cancer and Reproductive Harm -


Customer Reviews

Questions & Answers